Come era lecito aspettarsi,Uncharted 2: Il Covo Dei Ladri,è stato il più premiato,con ben tre categorie a carico,Miglior Gioco dell'anno,Migliore Grafica e ovviamente Miglior Gioco Playstation 3.Di seguito tutti i vincitori di quest'anno.
- Game of the Year: Uncharted 2: Among Thieves
- Studio of the Year: Rocksteady Studios
- Best Independent Game Fueld by Dew: Flower
- Best Xbox 360 Game: Left 4 Dead 2
- Best PS3 Game: Uncharted 2: Among Thieves
- Best Wii Game: New Super Mario Bros. Wii
- Best PC Game: Dragon Age: Origins
- Best Handheld Game: Grand Theft Auto: Chinatown Wars
- Best Shooter: Call of Duty: Modern Warfare 2
- Best Fighting Game: Street Fighter IV
- Best Action Adventure Game: Assassin's Creed II
- Best RPG: Dragon Age: Origins
- Best Multiplayer Game: Call of Duty: Modern Warfare 2
- Best Individual Sports Game: UFC 2009 Undisputed
- Best Team Sports Game: NHL 10
- Best Driving Game: Forza Motorsport 3
- Best Music Game: The Beatles: Rock Band
- Best Soundtrack: DJ Hero
- Best Original Score: Halo 3: ODST
- Best Graphics: Uncharted 2: Among Thieves
- Best Game Based On A Movie/TV Show: South Park Let's Go Tower Defense Play!
- Best Performance By A Human Female: Megan Fox as Mikaela Banes in Transformers: Revenge of the Fallen
- Best Performance By A Human Male: Hugh Jackman as Wolverine in X-Men Origins: Wolverine
- Best Cast: X-Men Origins: Wolverine
- Best Voice: Jack Black in Brutal Legend'
- Best Downloadable Game: Shadow Complex
- Best DLC: Grand Theft Auto: The Ballad of Gay Tony
- Most Anticipated Game of 2010: God of War III
